Synthesis of 2′-Fluoro RNA by Syn5 RNA polymerase

The substitution of 2′-fluoro for 2′-hydroxyl moieties in RNA substantially improves the stability of RNA. RNA stability is a major issue in RNA research and applications involving RNA. We report that the RNA polymerase from the marine cyanophage Syn5 has an intrinsic low discrimination against the...

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Detalles Bibliográficos
Autores principales: Zhu, Bin, Hernandez, Alfredo, Tan, Min, Wollenhaupt, Jan, Tabor, Stanley, Richardson, Charles C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538805/
https://www.ncbi.nlm.nih.gov/pubmed/25897116
http://dx.doi.org/10.1093/nar/gkv367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538805/
https://www.ncbi.nlm.nih.gov/pubmed/25897116
http://dx.doi.org/10.1093/nar/gkv367

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