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A predictive biophysical model of translational coupling to coordinate and control protein expression in bacterial operons

Natural and engineered genetic systems require the coordinated expression of proteins. In bacteria, translational coupling provides a genetically encoded mechanism to control expression level ratios within multi-cistronic operons. We have developed a sequence-to-function biophysical model of transla...

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Detalles Bibliográficos
Autores principales: Tian, Tian, Salis, Howard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538824/
https://www.ncbi.nlm.nih.gov/pubmed/26117546
http://dx.doi.org/10.1093/nar/gkv635