Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance

FOXM1 has been implicated in taxane resistance, but the molecular mechanism involved remains elusive. In here, we show that FOXM1 depletion can sensitize breast cancer cells and mouse embryonic fibroblasts into entering paclitaxel-induced senescence, with the loss of clonogenic ability, and the indu...

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Detalles Bibliográficos
Autores principales: Khongkow, P, Gomes, A R, Gong, C, Man, E P S, Tsang, J W-H, Zhao, F, Monteiro, L J, Coombes, R C, Medema, R H, Khoo, U S, Lam, E W-F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538879/
https://www.ncbi.nlm.nih.gov/pubmed/25961928
http://dx.doi.org/10.1038/onc.2015.152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538879/
https://www.ncbi.nlm.nih.gov/pubmed/25961928
http://dx.doi.org/10.1038/onc.2015.152

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