Viral Nucleases Induce an mRNA Degradation-Transcription Feedback Loop in Mammalian Cells

Gamma-herpesviruses encode a cytoplasmic mRNA-targeting endonuclease, SOX, that cleaves most cellular mRNAs. Cleaved fragments are subsequently degraded by the cellular 5′-3′ mRNA exonuclease Xrn1, thereby suppressing cellular gene expression and facilitating viral evasion of host defenses. We revea...

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Detalles Bibliográficos
Autores principales: Abernathy, Emma, Gilbertson, Sarah, Alla, Ravi, Glaunsinger, Britt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538998/
https://www.ncbi.nlm.nih.gov/pubmed/26211836
http://dx.doi.org/10.1016/j.chom.2015.06.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538998/
https://www.ncbi.nlm.nih.gov/pubmed/26211836
http://dx.doi.org/10.1016/j.chom.2015.06.019

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