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Viral Nucleases Induce an mRNA Degradation-Transcription Feedback Loop in Mammalian Cells
Gamma-herpesviruses encode a cytoplasmic mRNA-targeting endonuclease, SOX, that cleaves most cellular mRNAs. Cleaved fragments are subsequently degraded by the cellular 5′-3′ mRNA exonuclease Xrn1, thereby suppressing cellular gene expression and facilitating viral evasion of host defenses. We revea...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538998/ https://www.ncbi.nlm.nih.gov/pubmed/26211836 http://dx.doi.org/10.1016/j.chom.2015.06.019 |