Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

Valproic acid (VPA) is mainly metabolized via glucuronide, which is hydrolyzed by β-glucuronidase and undergoes enterohepatic circulation. Amoxicillin/clavulanic acid (AMC) administration leads to decreased levels of β-glucuronidase-producing bacteria, suggesting that these antibiotics could interru...

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Detalles Bibliográficos
Autores principales: Lee, Soo-Yun, Huh, Wooseong, Jung, Jin Ah, Yoo, Hye Min, Ko, Jae-Wook, Kim, Jung-Ryul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539086/
https://www.ncbi.nlm.nih.gov/pubmed/26309401
http://dx.doi.org/10.2147/DDDT.S89464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539086/
https://www.ncbi.nlm.nih.gov/pubmed/26309401
http://dx.doi.org/10.2147/DDDT.S89464

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