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Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

Valproic acid (VPA) is mainly metabolized via glucuronide, which is hydrolyzed by β-glucuronidase and undergoes enterohepatic circulation. Amoxicillin/clavulanic acid (AMC) administration leads to decreased levels of β-glucuronidase-producing bacteria, suggesting that these antibiotics could interru...

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Detalles Bibliográficos
Autores principales:	Lee, Soo-Yun, Huh, Wooseong, Jung, Jin Ah, Yoo, Hye Min, Ko, Jae-Wook, Kim, Jung-Ryul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539086/ https://www.ncbi.nlm.nih.gov/pubmed/26309401 http://dx.doi.org/10.2147/DDDT.S89464

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