Stepwise design, synthesis, and in vitro antifungal screening of (Z)-substituted-propenoic acid derivatives with potent broad-spectrum antifungal activity

Fungal infections are a main reason for the high mortality rate worldwide. It is a challenge to design selective antifungal agents with broad-spectrum activity. Lanosterol 14α-demethylase is an attractive target in the design of antifungal agents. Seven compounds were selected from a number of desig...

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Detalles Bibliográficos
Autor principal: Khedr, Mohammed A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539092/
https://www.ncbi.nlm.nih.gov/pubmed/26309398
http://dx.doi.org/10.2147/DDDT.S84178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539092/
https://www.ncbi.nlm.nih.gov/pubmed/26309398
http://dx.doi.org/10.2147/DDDT.S84178

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