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Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway
Increased stromal stiffness is associated with hepatocellular carcinoma (HCC) development and progression. However, the molecular mechanism by which matrix stiffness stimuli modulate HCC progress is largely unknown. In this study, we explored whether matrix stiffness-mediated effects on osteopontin...
Autores principales: | You, Yang, Zheng, Qiongdan, Dong, Yinying, Wang, Yaohui, Zhang, Lan, Xue, Tongchun, Xie, Xiaoying, Hu, Chao, Wang, Zhiming, Chen, Rongxin, Wang, Yanhong, Cui, Jiefeng, Ren, Zhenggang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539226/ https://www.ncbi.nlm.nih.gov/pubmed/26280346 http://dx.doi.org/10.1371/journal.pone.0134243 |
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