Impact of kinase activating and inactivating patient mutations on binary PKA interactions

The second messenger molecule cAMP links extracellular signals to intracellular responses. The main cellular cAMP effector is the compartmentalized protein kinase A (PKA). Upon receptor initiated cAMP-mobilization, PKA regulatory subunits (R) bind cAMP thereby triggering dissociation and activation...

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Detalles Bibliográficos
Autores principales: Röck, Ruth, Mayrhofer, Johanna E., Bachmann, Verena, Stefan, Eduard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539479/
https://www.ncbi.nlm.nih.gov/pubmed/26347651
http://dx.doi.org/10.3389/fphar.2015.00170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539479/
https://www.ncbi.nlm.nih.gov/pubmed/26347651
http://dx.doi.org/10.3389/fphar.2015.00170

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