Cargando…

Impact of kinase activating and inactivating patient mutations on binary PKA interactions

The second messenger molecule cAMP links extracellular signals to intracellular responses. The main cellular cAMP effector is the compartmentalized protein kinase A (PKA). Upon receptor initiated cAMP-mobilization, PKA regulatory subunits (R) bind cAMP thereby triggering dissociation and activation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Röck, Ruth, Mayrhofer, Johanna E., Bachmann, Verena, Stefan, Eduard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539479/ https://www.ncbi.nlm.nih.gov/pubmed/26347651 http://dx.doi.org/10.3389/fphar.2015.00170

Ejemplares similares

Corrigendum: Impact of kinase activating and inactivating patient mutations on binary PKA interactions
por: Röck, Ruth, et al.
Publicado: (2015)

In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs
por: Röck, Ruth, et al.
Publicado: (2015)

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS
por: Röck, Ruth, et al.
Publicado: (2019)

Interplay of PKA and Rac: Fine-tuning of Rac localization and signaling
por: Bachmann, Verena A, et al.
Publicado: (2013)

BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-κB and Activating PKA/CREB
por: Li, Chuwen, et al.
Publicado: (2018)

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells
por: Haushalter, Kristofer J., et al.
Publicado: (2018)

GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein
por: He, Shijun, et al.
Publicado: (2019)

Monoamine Oxidase-B Inhibitor Reduction in Pro-Inflammatory Cytokines Mediated by Inhibition of cAMP-PKA/EPAC Signaling
por: Putnins, Edward E., et al.
Publicado: (2021)

Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies
por: Mayrhofer, Johanna E., et al.
Publicado: (2020)

Liquiritin Attenuates Pathological Cardiac Hypertrophy by Activating the PKA/LKB1/AMPK Pathway
por: Aiyasiding, Xiahenazi, et al.
Publicado: (2022)

Ca(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKII
por: Johnston, Alex S., et al.
Publicado: (2015)

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades
por: Stefan, Eduard, et al.
Publicado: (2011)

A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging
por: Chen, Yao, et al.
Publicado: (2014)

Corrigendum: A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging
por: Chen, Yao, et al.
Publicado: (2016)

Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway
por: Gao, Rongyin, et al.
Publicado: (2023)

Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes
por: Christian, Frank, et al.
Publicado: (2011)

The Rapid and Long-Lasting Antidepressant Effects of Iridoid Fraction in Gardenia Jasminoides J.Ellis Are Dependent on Activating PKA-CREB Signaling Pathway
por: Ren, Li, et al.
Publicado: (2022)

The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity
por: Xu, Jing, et al.
Publicado: (2023)

Quinacrine Has Preferential Anticancer Effects on Mesothelioma Cells With Inactivating NF2 Mutations
por: Oien, Derek B., et al.
Publicado: (2021)

Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3
por: Xie, Wei, et al.
Publicado: (2018)

Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate of Learning Strategy by Inhibition of PKA/CREB Pathway in Rats
por: Sun, Wei, et al.
Publicado: (2018)

The A(2B) Adenosine Receptor Modulates the Epithelial– Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells
por: Giacomelli, Chiara, et al.
Publicado: (2018)

Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial Barrier Disruption and Atherosclerosis via the cAMP/PKA/RhoA Signaling Pathway
por: Li, Linyi, et al.
Publicado: (2021)

Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells
por: Zhou, Jie, et al.
Publicado: (2022)

Biochanin A Regulates Key Steps of Inflammation Resolution in a Model of Antigen-Induced Arthritis via GPR30/PKA-Dependent Mechanism
por: Felix, Franciel Batista, et al.
Publicado: (2021)

Corrigendum: Dopamine homeostasis imbalance and dopamine receptors-mediated AC/cAMP/PKA pathway activation are involved in aconitine-induced neurological impairment in zebrafish and SH-SY5Y cells
por: Zhou, Jie, et al.
Publicado: (2023)

Krukovine Suppresses KRAS-Mutated Lung Cancer Cell Growth and Proliferation by Inhibiting the RAF-ERK Pathway and Inactivating AKT Pathway
por: Lai, Huanling, et al.
Publicado: (2018)

Intermedin Inhibits the Ox-LDL–Induced Inflammation in RAW264.7 Cells by Affecting Fatty Acid–Binding Protein 4 Through the PKA Pathway
por: Liu, Kai, et al.
Publicado: (2021)

Interaction of TOR and PKA Signaling in S. cerevisiae
por: Plank, Michael
Publicado: (2022)

Voltage Sensor Inactivation in Potassium Channels
por: Bähring, Robert, et al.
Publicado: (2012)

A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, Na(V)1.2
por: Abdelsayed, Mena, et al.
Publicado: (2013)

Ginseng Compatibility Environment Attenuates Toxicity and Keeps Efficacy in Cor Pulmonale Treated by Fuzi Beimu Incompatibility Through the Coordinated Crosstalk of PKA and Epac Signaling Pathways
por: Huang, Yingying, et al.
Publicado: (2018)

β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway
por: Wu, Jiazhen, et al.
Publicado: (2021)

Targeting protein–protein interactions in complexes organized by A kinase anchoring proteins
por: Calejo, Ana I., et al.
Publicado: (2015)

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
por: Zhang, Jingliang, et al.
Publicado: (2021)

Protein Implicated in Nonsyndromic Mental Retardation Regulates Protein Kinase A (PKA) Activity
por: Al-Tawashi, Azza, et al.
Publicado: (2012)

Kinase cascades are binary to the bone
por: Dove, Alan W.
Publicado: (2004)

The Binary Classification of Protein Kinases
por: Elkoshi, Zeev
Publicado: (2021)

The Rate of NF-κB Nuclear Translocation Is Regulated by PKA and A Kinase Interacting Protein 1
por: King, Charles C., et al.
Publicado: (2011)

Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA)
por: Søberg, Kristoffer, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_bnh82fdq9iv18l1h7or5pj10fa