A nuclear role for the respiratory enzyme CLK-1/COQ7 in regulating mitochondrial stress responses and longevity

The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing. Mitochondria communicate with nuclei via retrograde signalling pathways that modulate nuclear gene expression in order...

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Detalles Bibliográficos
Autores principales: Monaghan, Richard M., Barnes, Robert G., Fisher, Kate, Andreou, Tereza, Rooney, Nicholas, Poulin, Gino B., Whitmarsh, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539581/
https://www.ncbi.nlm.nih.gov/pubmed/25961505
http://dx.doi.org/10.1038/ncb3170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539581/
https://www.ncbi.nlm.nih.gov/pubmed/25961505
http://dx.doi.org/10.1038/ncb3170

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