Paraspeckles: Paragons of functional aggregation

Low-complexity proteins undergo phase separation in vitro, forming hydrogels or liquid droplets. Whether these form in vivo, and under what conditions, is still unclear. In this issue, Hennig et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201504117) show that formation of the paraspeckle,...

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Detalles Bibliográficos
Autores principales: Courchaine, Edward, Neugebauer, Karla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539984/
https://www.ncbi.nlm.nih.gov/pubmed/26283795
http://dx.doi.org/10.1083/jcb.201507052
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author Courchaine, Edward
Neugebauer, Karla M.
author_facet Courchaine, Edward
Neugebauer, Karla M.
author_sort Courchaine, Edward
collection PubMed
description Low-complexity proteins undergo phase separation in vitro, forming hydrogels or liquid droplets. Whether these form in vivo, and under what conditions, is still unclear. In this issue, Hennig et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201504117) show that formation of the paraspeckle, a nuclear body that regulates gene expression, requires low-complexity prion-like domains (PLDs) within paraspeckle proteins. The same proteins were shown to form hydrogels, shedding light on the role of “functional aggregation” in nuclear substructure.
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spelling pubmed-45399842016-02-17 Paraspeckles: Paragons of functional aggregation Courchaine, Edward Neugebauer, Karla M. J Cell Biol Reviews Low-complexity proteins undergo phase separation in vitro, forming hydrogels or liquid droplets. Whether these form in vivo, and under what conditions, is still unclear. In this issue, Hennig et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201504117) show that formation of the paraspeckle, a nuclear body that regulates gene expression, requires low-complexity prion-like domains (PLDs) within paraspeckle proteins. The same proteins were shown to form hydrogels, shedding light on the role of “functional aggregation” in nuclear substructure. The Rockefeller University Press 2015-08-17 /pmc/articles/PMC4539984/ /pubmed/26283795 http://dx.doi.org/10.1083/jcb.201507052 Text en © 2015 Neugebauer and Courchaine This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Courchaine, Edward
Neugebauer, Karla M.
Paraspeckles: Paragons of functional aggregation
title Paraspeckles: Paragons of functional aggregation
title_full Paraspeckles: Paragons of functional aggregation
title_fullStr Paraspeckles: Paragons of functional aggregation
title_full_unstemmed Paraspeckles: Paragons of functional aggregation
title_short Paraspeckles: Paragons of functional aggregation
title_sort paraspeckles: paragons of functional aggregation
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539984/
https://www.ncbi.nlm.nih.gov/pubmed/26283795
http://dx.doi.org/10.1083/jcb.201507052
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