TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Replication stress delays replication into G2/M, which in turn impairs proper chromosome segregation and inflicts DNA damage on the daughter cells. Here we show that TopBP1 forms foci upon mitotic...

Descripción completa

Detalles Bibliográficos
Autores principales: Pedersen, Rune Troelsgaard, Kruse, Thomas, Nilsson, Jakob, Oestergaard, Vibe H., Lisby, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539992/
https://www.ncbi.nlm.nih.gov/pubmed/26283799
http://dx.doi.org/10.1083/jcb.201502107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539992/
https://www.ncbi.nlm.nih.gov/pubmed/26283799
http://dx.doi.org/10.1083/jcb.201502107

Ejemplares similares