Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis

The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as they moved from the apical region of the RPE....

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Mei, Esteve-Rudd, Julian, Lopes, Vanda S., Diemer, Tanja, Lillo, Concepción, Rump, Agrani, Williams, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539993/
https://www.ncbi.nlm.nih.gov/pubmed/26261180
http://dx.doi.org/10.1083/jcb.201410112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539993/
https://www.ncbi.nlm.nih.gov/pubmed/26261180
http://dx.doi.org/10.1083/jcb.201410112

Ejemplares similares