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Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis
The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as they moved from the apical region of the RPE....
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539993/ https://www.ncbi.nlm.nih.gov/pubmed/26261180 http://dx.doi.org/10.1083/jcb.201410112 |