A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy

Glioblastomas (GBMs) are very aggressive tumors with low chemosensitivity. The DNA-alkylating agent temozolomide (TMZ) is currently the most efficient chemotoxic drug for GBM therapy; however, many patients develop resistance to TMZ. Combining TMZ with another agent could present an improved treatme...

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Detalles Bibliográficos
Autores principales: Noack, J, Choi, J, Richter, K, Kopp-Schneider, A, Régnier-Vigouroux, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540206/
https://www.ncbi.nlm.nih.gov/pubmed/25255218
http://dx.doi.org/10.1038/cddis.2014.384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540206/
https://www.ncbi.nlm.nih.gov/pubmed/25255218
http://dx.doi.org/10.1038/cddis.2014.384

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