Cargando…
Restoration of Vision with Ectopic Expression of Human Rod Opsin
Many retinal dystrophies result in photoreceptor loss, but the inner retinal neurons can survive, making them potentially amenable to emerging optogenetic therapies. Here, we show that ectopically expressed human rod opsin, driven by either a non-selective or ON-bipolar cell-specific promoter, can f...
Autores principales: | Cehajic-Kapetanovic, Jasmina, Eleftheriou, Cyril, Allen, Annette E., Milosavljevic, Nina, Pienaar, Abigail, Bedford, Robert, Davis, Katherine E., Bishop, Paul N., Lucas, Robert J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540256/ https://www.ncbi.nlm.nih.gov/pubmed/26234216 http://dx.doi.org/10.1016/j.cub.2015.07.029 |
Ejemplares similares
-
Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin
por: Eleftheriou, Cyril G., et al.
Publicado: (2017) -
AAV Induced Expression of Human Rod and Cone Opsin in Bipolar Cells of a Mouse Model of Retinal Degeneration
por: McClements, Michelle E., et al.
Publicado: (2021) -
Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice
por: Cehajic-Kapetanovic, Jasmina, et al.
Publicado: (2017) -
Chemogenetic Activation of ipRGCs Drives Changes in Dark-Adapted (Scotopic) Electroretinogram
por: Milosavljevic, Nina, et al.
Publicado: (2016) -
Chemogenetic Activation of Melanopsin Retinal Ganglion Cells Induces Signatures of Arousal and/or Anxiety in Mice
por: Milosavljevic, Nina, et al.
Publicado: (2016)