A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp

BACKGROUND: Two meningococcal serogroup B vaccines contain Factor H binding protein (FHbp). Binding of Factor H (FH) to FHbp was thought to be specific for human or chimpanzee FH. However, in a previous study an amino acid polymorphism in rhesus macaque FH domain 6, tyrosine at position 352 (Y352) w...

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Detalles Bibliográficos
Autores principales: Konar, Monica, Beernink, Peter T., Granoff, Dan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540320/
https://www.ncbi.nlm.nih.gov/pubmed/26285122
http://dx.doi.org/10.1371/journal.pone.0135996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540320/
https://www.ncbi.nlm.nih.gov/pubmed/26285122
http://dx.doi.org/10.1371/journal.pone.0135996

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