Tricyclic analogues of epidithiodioxopiperazine alkaloids with promising in vitro and in vivo antitumor activity

Epipolythiodioxopiperazine (ETP) alkaloids are structurally elaborate alkaloids that show potent antitumor activity. However, their high toxicity and demonstrated interactions with various biological receptors compromises their therapeutic potential. In an effort to mitigate these disadvantages, a s...

Descripción completa

Detalles Bibliográficos
Autores principales: Baumann, Marcus, Dieskau, André P., Loertscher, Brad M., Walton, Mary C., Nam, Sangkil, Xie, Jun, Horne, David, Overman, Larry E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540405/
https://www.ncbi.nlm.nih.gov/pubmed/26301062
http://dx.doi.org/10.1039/c5sc01536g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540405/
https://www.ncbi.nlm.nih.gov/pubmed/26301062
http://dx.doi.org/10.1039/c5sc01536g

Ejemplares similares