New Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA

The rimJ gene, which codes for a crotonyl-CoA carboxylase/reductase, lies within the biosynthetic gene cluster for two polyketides belonging to the polyene macrolide group (CE-108 and rimocidin) produced by Streptomyces diastaticus var. 108. Disruption of rimJ by insertional inactivation gave rise t...

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Detalles Bibliográficos
Autores principales: Escudero, Leticia, Al-Refai, Mahmoud, Nieto, Cristina, Laatsch, Hartmut, Malpartida, Francisco, Seco, Elena M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540446/
https://www.ncbi.nlm.nih.gov/pubmed/26284936
http://dx.doi.org/10.1371/journal.pone.0135891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540446/
https://www.ncbi.nlm.nih.gov/pubmed/26284936
http://dx.doi.org/10.1371/journal.pone.0135891

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