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New Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA
The rimJ gene, which codes for a crotonyl-CoA carboxylase/reductase, lies within the biosynthetic gene cluster for two polyketides belonging to the polyene macrolide group (CE-108 and rimocidin) produced by Streptomyces diastaticus var. 108. Disruption of rimJ by insertional inactivation gave rise t...
Autores principales: | Escudero, Leticia, Al-Refai, Mahmoud, Nieto, Cristina, Laatsch, Hartmut, Malpartida, Francisco, Seco, Elena M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540446/ https://www.ncbi.nlm.nih.gov/pubmed/26284936 http://dx.doi.org/10.1371/journal.pone.0135891 |
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