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Covariation Is a Poor Measure of Molecular Coevolution

Recent developments in the analysis of amino acid covariation are leading to breakthroughs in protein structure prediction, protein design, and prediction of the interactome. It is assumed that observed patterns of covariation are caused by molecular coevolution, where substitutions at one site affe...

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Detalles Bibliográficos
Autores principales: Talavera, David, Lovell, Simon C., Whelan, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540965/
https://www.ncbi.nlm.nih.gov/pubmed/25944916
http://dx.doi.org/10.1093/molbev/msv109