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Covariation Is a Poor Measure of Molecular Coevolution
Recent developments in the analysis of amino acid covariation are leading to breakthroughs in protein structure prediction, protein design, and prediction of the interactome. It is assumed that observed patterns of covariation are caused by molecular coevolution, where substitutions at one site affe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540965/ https://www.ncbi.nlm.nih.gov/pubmed/25944916 http://dx.doi.org/10.1093/molbev/msv109 |