Cezanne regulates E2F1-dependent HIF2α expression

Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF). Under normal O(2) tension, HIFα subunits are targeted for proteasomal degradation, mainly through vHL-dependent ubiquitylation. Deubiquitylases are resp...

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Detalles Bibliográficos
Autores principales: Moniz, Sonia, Bandarra, Daniel, Biddlestone, John, Campbell, Kirsteen J., Komander, David, Bremm, Anja, Rocha, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541044/
https://www.ncbi.nlm.nih.gov/pubmed/26148512
http://dx.doi.org/10.1242/jcs.168864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541044/
https://www.ncbi.nlm.nih.gov/pubmed/26148512
http://dx.doi.org/10.1242/jcs.168864

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