Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes

Human ageing affects the immune system resulting in an overall decline in immunocompetence. Although all immune cells are affected during aging, the functional capacity of T cells is most influenced and is linked to decreased responsiveness to infections and impaired differentiation. We studied age-...

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Detalles Bibliográficos
Autores principales: Tserel, Liina, Kolde, Raivo, Limbach, Maia, Tretyakov, Konstantin, Kasela, Silva, Kisand, Kai, Saare, Mario, Vilo, Jaak, Metspalu, Andres, Milani, Lili, Peterson, Pärt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541364/
https://www.ncbi.nlm.nih.gov/pubmed/26286994
http://dx.doi.org/10.1038/srep13107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541364/
https://www.ncbi.nlm.nih.gov/pubmed/26286994
http://dx.doi.org/10.1038/srep13107

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