A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer Cells

The c-MYC proto-oncogene is a regulator of fundamental cellular processes such as cell cycle progression and apoptosis. The development of novel c-MYC inhibitors that can act by targeting the c-MYC DNA G-quadruplex at the level of transcription would provide potential insight into structure-based de...

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Detalles Bibliográficos
Autores principales: Panda, Deepanjan, Debnath, Manish, Mandal, Samir, Bessi, Irene, Schwalbe, Harald, Dash, Jyotirmayee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541407/
https://www.ncbi.nlm.nih.gov/pubmed/26286633
http://dx.doi.org/10.1038/srep13183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541407/
https://www.ncbi.nlm.nih.gov/pubmed/26286633
http://dx.doi.org/10.1038/srep13183

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