Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

BACKGROUND: Relaxin (RLX) can prevent cardiac fibrosis. We aimed to investigate the possible mechanism and signal transduction pathway of RLX inhibiting cardiac fibrosis. METHODS: Isoproterenol (5 mg·kg(−1)·d(−1)) was used to establish the cardiac fibrosis model in rats, which were administered RLX....

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Detalles Bibliográficos
Autores principales: Zhou, X, Chen, X, Cai, JJ, Chen, LZ, Gong, YS, Wang, LX, Gao, Z, Zhang, HQ, Huang, WJ, Zhou, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541540/
https://www.ncbi.nlm.nih.gov/pubmed/26316699
http://dx.doi.org/10.2147/DDDT.S85399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541540/
https://www.ncbi.nlm.nih.gov/pubmed/26316699
http://dx.doi.org/10.2147/DDDT.S85399

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