PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

Phosphatase and tensin homolog (PTEN), a well-known tumor suppressor gene and frequently mutated or lost in breast cancer, possesses the negative regulation function over the PI3K/Akt/mTOR pathway. PTEN insufficiency has been associated with advanced breast cancer and poor prognosis of breast cancer...

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Detalles Bibliográficos
Autores principales: Chiang, Kun-Chun, Chen, Huang-Yang, Hsu, Shu-Yuan, Pang, Jong-Hwei S, Wang, Shang-Yu, Hsu, Jun-Te, Yeh, Ta-Sen, Chen, Li-Wei, Kuo, Sheng-Fong, Sun, Chi-Chin, Lee, Jim-Ming, Yeh, Chun-Nan, Juang, Horng-Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541544/
https://www.ncbi.nlm.nih.gov/pubmed/26316702
http://dx.doi.org/10.2147/DDDT.S86184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541544/
https://www.ncbi.nlm.nih.gov/pubmed/26316702
http://dx.doi.org/10.2147/DDDT.S86184

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