The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum (ER) to a disturbance in protein folding. The so-called ER stress sensors PERK, IRE1 and ATF6 play a central role in the initiation and regulation of the UPR. The accumulation of misfolded and aggregated proteins i...

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Detalles Bibliográficos
Autores principales: Scheper, Wiep, Hoozemans, Jeroen J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541706/
https://www.ncbi.nlm.nih.gov/pubmed/26210990
http://dx.doi.org/10.1007/s00401-015-1462-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541706/
https://www.ncbi.nlm.nih.gov/pubmed/26210990
http://dx.doi.org/10.1007/s00401-015-1462-8

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