Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy

Diabetic neuropathy (DNP), afflicting sensory and motor nerve fibers, is a major complication in diabetes. The underlying cellular mechanisms of axon degeneration are poorly understood. IGFBP5, an inhibitory binding protein for insulin-like growth factor 1 (IGF1) is highly up-regulated in nerve biop...

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Detalles Bibliográficos
Autores principales: Simon, Christian M., Rauskolb, Stefanie, Gunnersen, Jennifer M., Holtmann, Bettina, Drepper, Carsten, Dombert, Benjamin, Braga, Massimiliano, Wiese, Stefan, Jablonka, Sibylle, Pühringer, Dirk, Zielasek, Jürgen, Hoeflich, Andreas, Silani, Vincenzo, Wolf, Eckhard, Kneitz, Susanne, Sommer, Claudia, Toyka, Klaus V., Sendtner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541707/
https://www.ncbi.nlm.nih.gov/pubmed/26025657
http://dx.doi.org/10.1007/s00401-015-1446-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541707/
https://www.ncbi.nlm.nih.gov/pubmed/26025657
http://dx.doi.org/10.1007/s00401-015-1446-8

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