Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/−) leukemia

BACKGROUND: B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading causes of childhood cancer-related mortality. Its most common chromosomal aberration is the ETV6-RUNX1 fusion gene, with ~25 % of ETV6-RUNX1 patients also carrying PAX5 alterations. METHODS: We have recreated th...

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Detalles Bibliográficos
Autores principales: van der Weyden, Louise, Giotopoulos, George, Wong, Kim, Rust, Alistair G., Robles-Espinoza, Carla Daniela, Osaki, Hikari, Huntly, Brian J., Adams, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542115/
https://www.ncbi.nlm.nih.gov/pubmed/26269126
http://dx.doi.org/10.1186/s12885-015-1586-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542115/
https://www.ncbi.nlm.nih.gov/pubmed/26269126
http://dx.doi.org/10.1186/s12885-015-1586-1

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