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Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/−) leukemia

BACKGROUND: B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading causes of childhood cancer-related mortality. Its most common chromosomal aberration is the ETV6-RUNX1 fusion gene, with ~25 % of ETV6-RUNX1 patients also carrying PAX5 alterations. METHODS: We have recreated th...

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Detalles Bibliográficos
Autores principales:	van der Weyden, Louise, Giotopoulos, George, Wong, Kim, Rust, Alistair G., Robles-Espinoza, Carla Daniela, Osaki, Hikari, Huntly, Brian J., Adams, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542115/ https://www.ncbi.nlm.nih.gov/pubmed/26269126 http://dx.doi.org/10.1186/s12885-015-1586-1

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