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Inhaled Nitric Oxide as an Adjunctive Treatment for Cerebral Malaria in Children: A Phase II Randomized Open-Label Clinical Trial

Background. Children with cerebral malaria (CM) have high rates of mortality and neurologic sequelae. Nitric oxide (NO) metabolite levels in plasma and urine are reduced in CM. Methods. This randomized trial assessed the efficacy of inhaled NO versus nitrogen (N(2)) as an adjunctive treatment for CM...

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Detalles Bibliográficos
Autores principales: Mwanga-Amumpaire, Juliet, Carroll, Ryan W., Baudin, Elisabeth, Kemigisha, Elisabeth, Nampijja, Dorah, Mworozi, Kenneth, Santorino, Data, Nyehangane, Dan, Nathan, Daniel I., De Beaudrap, Pierre, Etard, Jean-François, Feelisch, Martin, Fernandez, Bernadette O., Berssenbrugge, Annie, Bangsberg, David, Bloch, Kenneth D., Boum, Yap, Zapol, Warren M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542141/
https://www.ncbi.nlm.nih.gov/pubmed/26309894
http://dx.doi.org/10.1093/ofid/ofv111