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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response
The high-risk human papillomavirus E6 (hrHPV E6) protein has been widely studied due to its implication in cervical cancer. In response to viral threat, activated kinases phosphorylate the IRF3 autoinhibitory domain, inducing type1 interferon production. HPV circumvents the antiviral response throug...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542336/ https://www.ncbi.nlm.nih.gov/pubmed/26289783 http://dx.doi.org/10.1038/srep13446 |