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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response

The high-risk human papillomavirus E6 (hrHPV E6) protein has been widely studied due to its implication in cervical cancer. In response to viral threat, activated kinases phosphorylate the IRF3 autoinhibitory domain, inducing type1 interferon production. HPV circumvents the antiviral response throug...

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Detalles Bibliográficos
Autores principales:	Shah, Masaud, Anwar, Muhammad Ayaz, Park, Seolhee, Jafri, Syyada Samra, Choi, Sangdun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542336/ https://www.ncbi.nlm.nih.gov/pubmed/26289783 http://dx.doi.org/10.1038/srep13446

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