Cargando…

GPR43 Potentiates β-Cell Function in Obesity

The intestinal microbiome can regulate host energy homeostasis and the development of metabolic disease. Here we identify GPR43, a receptor for bacterially produced short-chain fatty acids (SCFAs), as a modulator of microbiota-host interaction. β-Cell expression of GPR43 and serum levels of acetate,...

Descripción completa

Detalles Bibliográficos
Autores principales:	McNelis, Joanne C., Lee, Yun Sok, Mayoral, Rafael, van der Kant, Rik, Johnson, Andrew M.F., Wollam, Joshua, Olefsky, Jerrold M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2015
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542437/ https://www.ncbi.nlm.nih.gov/pubmed/26023106 http://dx.doi.org/10.2337/db14-1938

Ejemplares similares

β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation
por: Panaro, Brandon L., et al.
Publicado: (2017)

Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer
por: Chung, Heekyung, et al.
Publicado: (2014)

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
por: Mayoral, Rafael, et al.
Publicado: (2015)

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding
por: Kebede, Melkam, et al.
Publicado: (2008)

β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass
por: Peyot, Marie-Line, et al.
Publicado: (2010)

Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
por: Nagao, Mototsugu, et al.
Publicado: (2020)

An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β-Cell Mass Acquisition
por: Bartolomé, Alberto, et al.
Publicado: (2022)

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells
por: Kim, Wook, et al.
Publicado: (2011)

XPR1 Mediates the Pancreatic β-Cell Phosphate Flush
por: Barker, Christopher J., et al.
Publicado: (2021)

Virgin β-Cells at the Neogenic Niche Proliferate Normally and Mature Slowly
por: Lee, Sharon, et al.
Publicado: (2021)

γ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells
por: Braun, Matthias, et al.
Publicado: (2010)

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?
por: Ang, Zhiwei, et al.
Publicado: (2016)

Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure
por: Turban, Sophie, et al.
Publicado: (2012)

Bcl-2 and Bcl-x(L) Suppress Glucose Signaling in Pancreatic β-Cells
por: Luciani, Dan S., et al.
Publicado: (2013)

A Gpr120 Selective Agonist Improves Insulin Resistance and Chronic Inflammation
por: Oh, Da Young, et al.
Publicado: (2014)

Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation
por: Zhang, Pili, et al.
Publicado: (2015)

Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation
por: Bottino, Rita, et al.
Publicado: (2009)

Targeted Disruption of Pancreatic-Derived Factor (PANDER, FAM3B) Impairs Pancreatic β-Cell Function
por: Robert-Cooperman, Claudia E., et al.
Publicado: (2010)

Convergence of the Insulin and Serotonin Programs in the Pancreatic β-Cell
por: Ohta, Yasuharu, et al.
Publicado: (2011)

Regulated and Reversible Induction of Adult Human β-Cell Replication
por: Takane, Karen K., et al.
Publicado: (2012)

Inhibition of Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice
por: Bone, Robert N., et al.
Publicado: (2015)

Advanced Glycation End Products Are Direct Modulators of β-Cell Function
por: Coughlan, Melinda T., et al.
Publicado: (2011)

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass
por: Oh, Eunjin, et al.
Publicado: (2018)

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
por: Cullen, Kirsty S., et al.
Publicado: (2011)

Roles of IP(3)R and RyR Ca(2+) Channels in Endoplasmic Reticulum Stress and β-Cell Death
por: Luciani, Dan S., et al.
Publicado: (2009)

Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation
por: Velazquez-Garcia, Silvia, et al.
Publicado: (2011)

SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion
por: Chen, Zheng, et al.
Publicado: (2014)

Connective Tissue Growth Factor Modulates Adult β-Cell Maturity and Proliferation to Promote β-Cell Regeneration in Mice
por: Riley, Kimberly G., et al.
Publicado: (2015)

Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes
por: Stancill, Jennifer S., et al.
Publicado: (2017)

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response
por: Marasco, Michelle R., et al.
Publicado: (2018)

β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes
por: Gitelman, Stephen E., et al.
Publicado: (2023)

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
por: Dirice, Ercument, et al.
Publicado: (2016)

β-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes
por: Lee, Sooyeon, et al.
Publicado: (2022)

ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation
por: Metukuri, Mallikarjuna R., et al.
Publicado: (2012)

Pancreatic β-Cell–Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion
por: Burns, Christian H., et al.
Publicado: (2021)

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
por: Åkerfeldt, Mia C., et al.
Publicado: (2008)

Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus
por: Demirci, Cem, et al.
Publicado: (2012)

Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes
por: Wang, Linyuan, et al.
Publicado: (2010)

ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro
por: Docherty, Fiona M., et al.
Publicado: (2021)

Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes
por: Rosengren, Anders H., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_jvant5urkh62fmd3aqpnjotu97