SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice

Protein hyperacetylation is associated with glucose intolerance and insulin resistance, suggesting that the enzymes regulating the acetylome play a role in this pathological process. Sirtuin 3 (SIRT3), the primary mitochondrial deacetylase, has been linked to energy homeostasis. Thus, it is hypothes...

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Detalles Bibliográficos
Autores principales: Lantier, Louise, Williams, Ashley S., Williams, Ian M., Yang, Karen K., Bracy, Deanna P., Goelzer, Mickael, James, Freyja D., Gius, David, Wasserman, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542443/
https://www.ncbi.nlm.nih.gov/pubmed/25948682
http://dx.doi.org/10.2337/db14-1810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542443/
https://www.ncbi.nlm.nih.gov/pubmed/25948682
http://dx.doi.org/10.2337/db14-1810

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