Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1

Cyclic α-conotoxin Vc1.1 (cVc1.1) is an orally active peptide with analgesic activity in rat models of neuropathic pain. It has two disulfide bonds, which can have three different connectivities, one of which is the native and active form. In this study we used computational modeling and nuclear mag...

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Detalles Bibliográficos
Autores principales: Yu, Rilei, Seymour, Victoria A. L., Berecki, Géza, Jia, Xinying, Akcan, Muharrem, Adams, David J., Kaas, Quentin, Craik, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542547/
https://www.ncbi.nlm.nih.gov/pubmed/26290113
http://dx.doi.org/10.1038/srep13264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542547/
https://www.ncbi.nlm.nih.gov/pubmed/26290113
http://dx.doi.org/10.1038/srep13264

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