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Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA(1) N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation
Lysophosphatidic acid (LPA) receptor 1 (LPA(1)) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA(1) interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has been id...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542628/ https://www.ncbi.nlm.nih.gov/pubmed/26268898 http://dx.doi.org/10.1038/srep13343 |