Cargando…

Endosialin Expression in Metastatic Melanoma Tumor Microenvironment Vasculature: Potential Therapeutic Implications

Ontuxizumab (MORAb-004) is a humanized recombinant antibody targeting endosialin (TEM-1, CD248). We conducted an analysis of endosialin expression in metastatic melanoma specimens using the anti-endosialin rat anti- MAb 9G5, in order to determine the potential of endosialin as a therapeutic target w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kiyohara, Eiji, Donovan, Nicholas, Takeshima, Ling, Huang, Sharon, Wilmott, James S., Scolyer, Richard A., Jones, Peter, Somers, Elizabeth B., O’Shannessy, Daniel J., Hoon, Dave S. B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2015
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542822/ https://www.ncbi.nlm.nih.gov/pubmed/26085332 http://dx.doi.org/10.1007/s12307-015-0168-8

Ejemplares similares

Influence of tumor microenvironment on prognosis in colorectal cancer: Tissue architecture-dependent signature of endosialin (TEM-1) and associated proteins
por: O'Shannessy, Daniel J., et al.
Publicado: (2014)

Endosialin and Associated Protein Expression in Soft Tissue Sarcomas: A Potential Target for Anti-Endosialin Therapeutic Strategies
por: O'Shannessy, Daniel J., et al.
Publicado: (2016)

Novel antibody probes for the characterization of endosialin/TEM-1
por: O'shannessy, Daniel J., et al.
Publicado: (2016)

Development of (89)Zr-Ontuxizumab for in vivo TEM-1/endosialin PET applications
por: Lange, Sara E.S., et al.
Publicado: (2016)

Folate Receptor Alpha, Mesothelin and Megakaryocyte Potentiating Factor as Potential Serum Markers of Chronic Kidney Disease
por: Somers, Elizabeth B, et al.
Publicado: (2014)

Isolation of Circulating Tumor Cells from Multiple Epithelial Cancers with ApoStream(®) for Detecting (or Monitoring) the Expression of Folate Receptor Alpha
por: O’Shannessy, Daniel J., et al.
Publicado: (2016)

Folate receptor alpha (FRA) expression in breast cancer: identification of a new molecular subtype and association with triple negative disease
por: O’Shannessy, Daniel J, et al.
Publicado: (2012)

Expression of folate receptors alpha and beta in normal and cancerous gynecologic tissues: correlation of expression of the beta isoform with macrophage markers
por: O’Shannessy, Daniel J, et al.
Publicado: (2015)

Classification of the tumor immune microenvironment and associations with outcomes in patients with metastatic melanoma treated with immunotherapies
por: Adegoke, Nurudeen A, et al.
Publicado: (2023)

Feasibility of an Intensive, Disorder-Specific, Group-Based Cognitive Behavioural Therapy Intervention for Adolescents with Social Anxiety Disorder
por: O’Shannessy, Dustin M., et al.
Publicado: (2021)

Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites
por: Conway, Jordan W, et al.
Publicado: (2022)

Characterization of TEM1/endosialin in human and murine brain tumors
por: Carson-Walter, Eleanor B, et al.
Publicado: (2009)

Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4
por: O’Shannessy, Daniel J, et al.
Publicado: (2013)

Combined targeted therapy and immunotherapy in the treatment of advanced melanoma
por: Wilmott, James S., et al.
Publicado: (2012)

Endosialin defines human stem Leydig cells with regenerative potential
por: Xia, Kai, et al.
Publicado: (2020)

Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance
por: O'Shannessy, Daniel J., et al.
Publicado: (2012)

Gene Expression Analyses Support Fallopian Tube Epithelium as the Cell of Origin of Epithelial Ovarian Cancer
por: O’Shannessy, Daniel J., et al.
Publicado: (2013)

High-Dimensional Single-Cell Transcriptomics in Melanoma and Cancer Immunotherapy
por: Quek, Camelia, et al.
Publicado: (2021)

Characterization of the treatment-naive immune microenvironment in melanoma with BRAF mutation
por: Wang, Minyu, et al.
Publicado: (2022)

Proteomic phenotyping of metastatic melanoma reveals putative signatures of MEK inhibitor response and prognosis
por: Krisp, Christoph, et al.
Publicado: (2018)

Co-Development of Diagnostic Vectors to Support Targeted Therapies and Theranostics: Essential Tools in Personalized Cancer Therapy
por: Nicolaides, Nicholas C., et al.
Publicado: (2014)

The Parsortix™ Cell Separation System—A versatile liquid biopsy platform
por: Miller, M. Craig, et al.
Publicado: (2018)

The effect of organ-specific tumor microenvironments on response patterns to immunotherapy
por: Conway, Jordan W., et al.
Publicado: (2022)

Targeting NK Cells to Enhance Melanoma Response to Immunotherapies
por: Lee, Hansol, et al.
Publicado: (2021)

Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2
por: Ohradanova, A, et al.
Publicado: (2008)

A Differential Role for CD248 (Endosialin) in PDGF-Mediated Skeletal Muscle Angiogenesis
por: Naylor, Amy J., et al.
Publicado: (2014)

Endosialin-expressing bone sarcoma stem-like cells are highly tumor-initiating and invasive
por: SUN, DONG-XIU, et al.
Publicado: (2015)

Endosialin expression in soft tissue sarcoma as a potential marker of undifferentiated mesenchymal cells
por: Thway, Khin, et al.
Publicado: (2016)

Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin
por: Mogler, Carolin, et al.
Publicado: (2017)

No Significant Association Between Plasma Endosialin Levels and the Presence or Severity of Coronary Artery Disease
por: Kishimoto, Yoshimi, et al.
Publicado: (2022)

A Worrisome Case of Early In Situ Melanoma on the Leg: A Multicomponent Pattern in Dermoscopy Supportive of Malignancy
por: Kiyohara, Takahiro, et al.
Publicado: (2021)

Heterogeneity in the Metastatic Microenvironment: JunB-Expressing Microglia Cells as Potential Drivers of Melanoma Brain Metastasis Progression
por: Adir, Orit, et al.
Publicado: (2023)

Acetylated DNMT1 Downregulation and Related Regulatory Factors Influence Metastatic Melanoma Patients Survival
por: Zhang, Xiaoqing, et al.
Publicado: (2021)

Interleukin enhancer‐binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma
por: Zhang, Xiaoqing, et al.
Publicado: (2021)

The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells – a case of inter‐tumor heterogeneity
por: Izraely, Sivan, et al.
Publicado: (2020)

Overview of the Microenvironment of Vasculature in Vascular Tone Regulation
por: Loh, Yean Chun, et al.
Publicado: (2018)

Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage
por: Mogler, Carolin, et al.
Publicado: (2015)

Endosialin/CD248 may be a potential therapeutic target to prevent the invasion and metastasis in osteosarcoma
por: Kondo, Yumiko, et al.
Publicado: (2022)

Microenvironment-derived factors driving metastatic plasticity in melanoma
por: Kim, Isabella S., et al.
Publicado: (2017)

Multi-platform genome-wide analysis of melanoma progression to brain metastasis
por: Marzese, Diego M., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_84j8h3a3d6vqpb82m3jk33ndsr