Tunable and reversible drug control of protein production via a self-excising degron

An effective method for direct chemical control over the production of specific proteins would be widely useful. We describe Small Molecule-Assisted Shutoff (SMASh), a technique in which proteins are fused to a degron that removes itself in the absence of drug, leaving untagged protein. Clinically t...

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Detalles Bibliográficos
Autores principales: Chung, Hokyung K., Jacobs, Conor L., Huo, Yunwen, Yang, Jin, Krumm, Stefanie A., Plemper, Richard K., Tsien, Roger Y., Lin, Michael Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543534/
https://www.ncbi.nlm.nih.gov/pubmed/26214256
http://dx.doi.org/10.1038/nchembio.1869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543534/
https://www.ncbi.nlm.nih.gov/pubmed/26214256
http://dx.doi.org/10.1038/nchembio.1869

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