The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL

The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure. A critical step in the pathway is the monoubiquitination of FANCD2 by the RING E3 ligase FANCL. FA...

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Detalles Bibliográficos
Autores principales: Miles, Jennifer A., Frost, Mark G., Carroll, Eilis, Rowe, Michelle L., Howard, Mark J., Sidhu, Ateesh, Chaugule, Viduth K., Alpi, Arno F., Walden, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543658/
https://www.ncbi.nlm.nih.gov/pubmed/26149689
http://dx.doi.org/10.1074/jbc.M115.675835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543658/
https://www.ncbi.nlm.nih.gov/pubmed/26149689
http://dx.doi.org/10.1074/jbc.M115.675835

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