An excess of catalytically required motions inhibits the scavenger decapping enzyme

The scavenger decapping enzyme hydrolyses the protecting 5′ cap structure from short mRNAs that result from exosomal degradation. Based on static crystal structures and NMR data it is apparent that the dimeric enzyme has to undergo large structural changes to bind substrate in a catalytically compet...

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Detalles Bibliográficos
Autores principales: Neu, Ancilla, Neu, Ursula, Fuchs, Anna-Lisa, Schlager, Benjamin, Sprangers, Remco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544744/
https://www.ncbi.nlm.nih.gov/pubmed/26258763
http://dx.doi.org/10.1038/nchembio.1866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544744/
https://www.ncbi.nlm.nih.gov/pubmed/26258763
http://dx.doi.org/10.1038/nchembio.1866

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