Cargando…

Na,K-ATPase β(1)-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity

BACKGROUND: The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway are...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seung Joon, Litan, Alisa, Li, Zhiqin, Graves, Bruce, Lindsey, Stephan, Barwe, Sonali P., Langhans, Sigrid A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544806/ https://www.ncbi.nlm.nih.gov/pubmed/26286140 http://dx.doi.org/10.1186/s12943-015-0430-1

Ejemplares similares

Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma
por: Wolle, Daniel, et al.
Publicado: (2014)

Sonic Hedgehog-Induced Histone Deacetylase Activation Is Required for Cerebellar Granule Precursor Hyperplasia in Medulloblastoma
por: Lee, Seung Joon, et al.
Publicado: (2013)

Transcriptional regulators of Na,K-ATPase subunits
por: Li, Zhiqin, et al.
Publicado: (2015)

EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation
por: Lee, Seung Joon, et al.
Publicado: (2015)

Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma
por: Jenkins, Noah C, et al.
Publicado: (2014)

HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma
por: Bell, Jonathan B., et al.
Publicado: (2018)

Expression of Na,K-ATPase-β(1) subunit increases uptake and sensitizes carcinoma cells to oxaliplatin
por: Tummala, Ramakumar, et al.
Publicado: (2009)

The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma
por: He, Xuelian, et al.
Publicado: (2014)

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma
por: Brun, Sonja N., et al.
Publicado: (2014)

MBCL-21. GERMLINE ELONGATOR MUTATIONS IN SONIC HEDGEHOG MEDULLOBLASTOMA
por: Robinson, Giles W, et al.
Publicado: (2020)

Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo
por: MacDonald, Tobey J., et al.
Publicado: (2021)

Clinical and molecular analysis of smoothened inhibitors in Sonic Hedgehog medulloblastoma
por: Pereira, Victor, et al.
Publicado: (2021)

Generating a mouse model for relapsed Sonic Hedgehog medulloblastoma
por: Heller, Allie, et al.
Publicado: (2023)

Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma
por: Qu, Meiyu, et al.
Publicado: (2022)

MEDB-57.GNAS inactivation as a driver for sonic hedgehog-activated medulloblastoma
por: Goode, Erin, et al.
Publicado: (2022)

Cancer as a channelopathy: ion channels and pumps in tumor development and progression
por: Litan, Alisa, et al.
Publicado: (2015)

A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma
por: White, Christine L., et al.
Publicado: (2019)

Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
por: Maximov, Victor, et al.
Publicado: (2019)

Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma
por: Robinson, M. Hope, et al.
Publicado: (2019)

Effects of metformin on Sonic hedgehog subgroup medulloblastoma progression: In vitro and in vivo studies
por: Fang, Huangyi, et al.
Publicado: (2022)

KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasis
por: Sanghrajka, Reeti Mayur, et al.
Publicado: (2023)

Glucocorticoids Suppress Renal Cell Carcinoma Progression by Enhancing Na,K-ATPase Beta-1 Subunit Expression
por: Huynh, Thu P., et al.
Publicado: (2015)

WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma
por: Wen, Jing, et al.
Publicado: (2016)

G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
por: He, Xuelian, et al.
Publicado: (2014)

Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using the OLIG2 inhibitor CT-179
por: Li, Yuchen, et al.
Publicado: (2023)

YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog - dependent cerebellar granule neuron progenitor cells and medulloblastoma cells
por: Dey, Abhinav, et al.
Publicado: (2016)

Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks
por: Po, Agnese, et al.
Publicado: (2018)

MEDB-52. Organoids as preclinical models to improve and personalize disease outcome for sonic hedgehog medulloblastoma
por: Odé, Zelda, et al.
Publicado: (2022)

MEDB-02. The identification and functional characterization of circular RNA Circ_63706 in sonic hedgehog medulloblastomas
por: Pokhrel, Rudramani, et al.
Publicado: (2022)

The developmental stage of the medulloblastoma cell-of-origin restricts Sonic hedgehog pathway usage and drug sensitivity
por: Smit, Marlinde J., et al.
Publicado: (2022)

Sonic Hedgehog in SCLC
por: Laukkanen, Mikko O., et al.
Publicado: (2015)

An H3F3A K27M‐mutation in a sonic hedgehog medulloblastoma
por: Dottermusch, Matthias, et al.
Publicado: (2021)

MBRS-21. CLINICAL AGGRESSIVENESS OF TP53-WILD TYPE SONIC HEDGEHOG MEDULLOBLASTOMA WITH MYCN AMPLIFICATION
por: Mitani, Yuichi, et al.
Publicado: (2020)

MEDB-45. Functional genomics identifies epigenetic regulators as novel therapeutic targets for sonic hedgehog medulloblastoma
por: Tsiami, Foteini, et al.
Publicado: (2022)

IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma
por: Kunhiraman, Haritha, et al.
Publicado: (2023)

Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles
por: Soltys, Bohdan J., et al.
Publicado: (2023)

Tuning of the Na,K-ATPase by the beta subunit
por: Hilbers, Florian, et al.
Publicado: (2016)

Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and Medulloblastoma
por: Bhatia, Bobby, et al.
Publicado: (2010)

The oncogenic circular RNA circ_63706 is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas
por: Katsushima, Keisuke, et al.
Publicado: (2023)

Sonic hedgehog signaling in astrocytes
por: Hill, Steven A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2014l12r1qjj0v6qq2hd6qlcoa