Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

Aims: Loss-of-function mutations in GBA1, which cause the autosomal recessive lysosomal storage disease, Gaucher disease (GD), are also a key genetic risk factor for the α-synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy bodies. GBA1 encodes for the lysosomal hydrola...

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Detalles Bibliográficos
Autores principales: Rocha, Emily M., Smith, Gaynor A., Park, Eric, Cao, Hongmei, Graham, Anne-Renee, Brown, Eilish, McLean, Jesse R., Hayes, Melissa A., Beagan, Jonathan, Izen, Sarah C., Perez-Torres, Eduardo, Hallett, Penelope J., Isacson, Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Forum Original Research CommunicationsCNS Autophagy (B. McLaughlin, Ed.)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544823/
https://www.ncbi.nlm.nih.gov/pubmed/26094487
http://dx.doi.org/10.1089/ars.2015.6307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544823/
https://www.ncbi.nlm.nih.gov/pubmed/26094487
http://dx.doi.org/10.1089/ars.2015.6307

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