TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression

TNF induces bone loss in common bone diseases by promoting osteoclast formation directly and indirectly, but it also limits osteoclast formation by inducing expression of NF-κB p100. Osteoclast precursors (OCPs) are derived from M1 (inflammatory) and M2 (resident) macrophages. However, it is not kno...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Zhijun, Hou, Xiaodong, Yin, Xiaoxiang, Li, Yanyun, Duan, Rong, Boyce, Brendan F., Yao, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545392/
https://www.ncbi.nlm.nih.gov/pubmed/26287732
http://dx.doi.org/10.1371/journal.pone.0135728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545392/
https://www.ncbi.nlm.nih.gov/pubmed/26287732
http://dx.doi.org/10.1371/journal.pone.0135728

Ejemplares similares