Cargando…

Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle

Many proteins are known to promote ciliogenesis, but mechanisms that promote primary cilia disassembly before mitosis are largely unknown. Here we identify a mechanism that favours cilium disassembly and maintains the disassembled state. We show that co-localization of the S/G2 phase kinase, Nek2 an...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Sehyun, Lee, Kwanwoo, Choi, Jung-Hwan, Ringstad, Niels, Dynlacht, Brian David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545512/
https://www.ncbi.nlm.nih.gov/pubmed/26290419
http://dx.doi.org/10.1038/ncomms9087