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Disomy 21 in spermatozoa and the paternal origin of trisomy 21 Down syndrome
BACKGROUND: Trisomy 21 Down syndrome is the most common genetic cause for congenital malformations and intellectual disability. It is well known that in the outstanding majority of cases the extra chromosome 21 originates from the mother but only in less than 10 % from the father. The mechanism unde...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545544/ https://www.ncbi.nlm.nih.gov/pubmed/26300975 http://dx.doi.org/10.1186/s13039-015-0155-2 |