Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via the nuclear exit of a mechanorepressor

Scarring is a long-lasting problem in higher animals, and reductionist approaches could aid in developing treatments. Here, we show that co-polymerization of collagen-I with polyacrylamide produces minimal matrix models of scars (MMMS), in which fractal-fiber bundles segregate heterogeneously to the...

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Detalles Bibliográficos
Autores principales: P. Dingal, P. C. Dave, Bradshaw, Andrew M., Cho, Sangkyun, Raab, Matthew, Buxboim, Amnon, Swift, Joe, Discher, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545733/
https://www.ncbi.nlm.nih.gov/pubmed/26168347
http://dx.doi.org/10.1038/nmat4350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545733/
https://www.ncbi.nlm.nih.gov/pubmed/26168347
http://dx.doi.org/10.1038/nmat4350

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